Bart Alberts' thesis cover illustration, by Roselyne Chauvin. Thesis defended on 19 December 2016. The aim of his thesis was to unravel the brain underlying computational mechanisms regarding spatial orientation. Using psychophysics as a quantitative experimental approach and model simulations based on reverse engineering methods, his thesis provides us with new insights about spatial orientation processing in the brain of healthy subjects of all ages as well as bilateral vestibular patients.